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KMID : 1149220040120020095
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Korean Journal of Oriental Medical Prescription
2004 Volume.12 No. 2 p.95 ~ p.108
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Anti-inflammatory Effects of Gangyeong-Tang (康寧湯) on Mice injected LPS in Vagina
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Lee Tae-Hee
Yoon Jung-Moon
Lim Eun-Mee
Kim Yun-Sang
Cho Hyun-Ju
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Abstract
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Objective: We made the genital organs inflammatory mice model by vaginal injection of Lipopolysaccharide(LPS), and we intended to make study about anti-inflammatory effects of Gangyeong-Tang, among oral and rectal medication and Herbal-Acupuncture treatment.
Method: The female ICR(20-30g) mice were used, the temperature was controlled within and water and food was not limited. The environment was manipulated to simulate 12 hours of day and 12 hours of night. After LPS injection into vagina, we confirmed on-set of inflammation. 2 days before LPS injection, we started to medicate Gangyeong-Tang in Oral and Rectal and Aqua-acupucture treatment. After 3days from LPS injection, we mesured the White Blood Cell(WBC), Interrleukin-6(IL-6), Tumor Necrosis Factor-(TNF-) in blood which was collected from the Retro-orbital Plexus.
Results: 1. We made the genital organs inflammatory mice model by vaginal injection of LPS successfully. 2. The number of WBC was decreased significantly as we medicated Gangyeong- Tang in Oral 1g/kg dose, 3g/kg dose and Rectal 1g/kg dose, rectal 3g/kg dose. 3. The concentration of IL-6 was decreased significantly as we medicated Gangyeong-Tang in all group of the Oral, Rectal, Herbal-Acupuncture treatment. 4. The concentration of TNF- was decreased significantly as we medicated Gangyeong-Tang in Oral 3g/kg dose and Rectal 1g/kg dose, Rectal 3g/kg dose group. Herbal-Acupuncture treatment group datas showed reductive tendency.
Conclusion: As a result of this experiment, we made the genital organs inflammatory mice model by vaginal injection of LPS successfully and demonstrated anti-inflammatory effect of Gangyeong-Tang.
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KEYWORD
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Gangyeong-Tang, LPS, vagina injection, Rectal medication, PID, Herbal-Acupuncture treatment, Genital organs inflammation
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